ISSN : 0975-9492
CODEN : IJPSQQ





INTERNATIONAL JOURNAL OF PHARMA SCIENCES AND RESEARCH


Open Access

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ABSTRACT

Title : Validation of UV spectroscopy for simultaneous estimation of stavudine, lamivudine and nevirapine in tablet formulations
Authors : M.Rangapriya, Dr.N.N.Rajendran
Keywords : Stavudine; Lamivudine; Nevirapine; UV spectrophotometry; Simultaneous
Issue Date : October 2014
Abstract :
Mostly antiretroviral drugs are estimated using methods which require expensive equipment and trained technicians. Spectrophotometric method is relatively simple and accurate for the estimation of antiretroviral drugs in pharmaceutical formulations which is also cost effective when compared to other specialized methods. In the present study, simultaneous quantification of stavudine (STV), lamivudine (LMV) and nevirapine (NVP) by UV spectroscopy method was developed. The drugs STV, LMV and NVP were quantified at 266, 271 and 315 nm, respectively. Recovery values of 98.92 - 100.12 %, 99.40 100.13%, 99.01- 100.32% for STV, LMV and NVP respectively with percentage relative standard deviation of <1 shows that the developed method was accurate and precise. This method can be employed for the routine analysis of tablets containing STV, LMV and NVP as comparable to other methods requiring higher facilities.
Page(s) : 655-664
ISSN : 0975-9492
Source : Vol. 5, No.10