ISSN : 0975-9492


Open Access

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Title : Formulation and evaluation of gastro retentive floating tablets of Terbutaline sulphate
Authors : Lokesh Kumar, Virendra Singh, Rakesh Kumar Meel
Keywords : Terbutaline sulphate, gastro retentive, gastric floating tablet, floating drug delivery, controlled release.
Issue Date : October 2014
Abstract :
The purpose of this research was to develop a novel gastro retentive floating tablets of Terbutaline sulphate (TBS). Terbutaline sulphate has short half life (3-4 hrs) so an attempt has been made to Sustain the drug release by the incorporation of hydrophilic swellable polymer such as Hydroxy propyl methylcellulose (HPMC) and present it in the form of gastro retentive floating tablets, which after oral administration are designed to provide the desired controlled and complete release of drug for prolonged period of time in the treatment of Asthma. Floating effervescent tablets were formulated using various grades of hydroxy propyl methylcellulose (HPMC K4M, HPMC K15M and HPMC K100M), and gas generating agent like sodium bicarbonate. The concentration of this agent was also optimized to get desired controlled release of drug. The floating tablet formulations were evaluated for physical characterization, hardness, friability, weight variation, drug content uniformity, swelling index and buoyancy studies. The results indicated that the optimized intragastric floating (IGF) tablet (F9) composed of 50 mg HPMC K100M and 18 mg MCC, exhibited 95.28% drug release in 12 h, while the buoyancy lag time was 10.33 sec, and the intragastric floating tablet remained buoyant for 24 h. Optimized intragastric floating tablet showed no significant change in physical appearance, drug content, total buoyancy time, or in vitro dissolution pattern after storage at 40C/75% relative humidity for 1 month.
Page(s) : 639-645
ISSN : 0975-9492
Source : Vol. 5, No.10