ISSN : 0975-9492


Open Access

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Title : Reasons for Anti-Retroviral Regimen Changes in HIV/AIDS patients of Ayder Referral Hospital ART clinic, Mekelle, Ethiopia.
Keywords : HAART, HIV/AIDS, reasons, regimen switch, Ayder referral hospital
Issue Date : October 2014
Abstract :
This study was performed to determine the reasons of anti-retroviral regimen changes among HIV/AIDS patients of Ayder referral hospital, ART clinic. It was conducted using a retrospective institution based cross-sectional study from April 22, 2013-May 22, 2013, by preparing pre-tested questioner and reviewing the patientís information cards. Out of 720 patients who were taking antiretroviral therapy, 157 of them have switched their regimen and all of the Patient cards who changed from the initial treatment regimen were assessed and analyzed using SPSS version 20.0.The study have showed that out of the patients who switched their regimen, majority 80 (51%) were male. The main reason for regimen change was toxicity which accounted for 119 (75.8%) followed by tuberculosis 22 (14.01%), treatment failure 15 (9.55%) and pregnancy 1 (0.64%). The major type of toxicity was anemia which accounted for 47 (39.8%) followed by peripheral neuropathy 32 (27.1%), lipatrophy 21 (17.8%), rash 11 (9.3%), Central nervous system toxicity 5 (4.2%), hepatotoxicity and renal failure taking up 1 (0.8%) each. The major toxicity causing anti-retroviral drug was Stavudine 54 (45.4%) followed by Zidovudine 47 (39.5%), Nevirapine 12 (10.1%), Efavirenz 5 (4.2%) and Tenofovir 1 (0.8%). Out of the patients who switched their regimens, 16 (10.2%) of them switched twice and 1(0.6%) thrice. The main reason for the second switch was toxicity 15 (93.75%) and treatment failure 1 (6.25%). The reason for thrice switch was toxicity (100%). Toxicity was the main reason for modification of the regimen followed by tuberculosis, treatment failure and pregnancy, respectively.
Page(s) : 693-700
ISSN : 0975-9492
Source : Vol. 5, No.10