ISSN : 0975-9492
CODEN : IJPSQQ





INTERNATIONAL JOURNAL OF PHARMA SCIENCES AND RESEARCH


Open Access

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ABSTRACT

Title : Cytotoxic Activity of Three South Sulawesi Medicinal Plant Extracts Used in the Treatment of HeLa Cell Line: Jati Putih (Gmelina arborea Roxb.), Jati Belanda (Guazuma ulmifolia Lamk.) and Lakkalakka (Curculigo orchioides Gaerth)
Authors : LUKMAN M, RENY SYAHRUNI, MICHRUN NISA, AISYAH FATMAWATI
Keywords : Cytotoxic, HeLa, Gmelina arborea Roxb, Guazuma ulmifolia Lamk and Curculigo orchioides Gaerth
Issue Date : September 2014
Abstract :
Gmelina arborea Roxb, Guazuma ulmifolia Lamk and Curculigo orchioides Gaerth, the three plants frequently used in South Sulawesi for the treatment of cancerous diseases, have been selected to examine their action in cervical epithelial carcinoma. These extracts were assessed using HeLa cell cancer (Human cervix cancer) and doxorubicin was used as the positive control. Data are presented as the dose that inhibited 50% control growth (IC50). Cytotoxic activity was measured using MTT colorimetric assay. Dose-dependent studies revealed IC50 of 113.610.12 g/mL, 174.901.22 g/mL and 126.052.43 g/mL for eGA, eGU and eCO on HeLa cell cancer, respectively and correlated with treatment of cancer.
Page(s) : 531-536
ISSN : 0975-9492
Source : Vol. 5, No.9