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ABSTRACT
| Title |
: |
Kinetics of butyrylcholinesterase inhibition by an ethanolic extract of Shorea robusta |
| Authors |
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Chandra Shekhar, Suresh Kumar |
| Keywords |
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Butyrylcholinesterase, Shorea robusta, Inhibition, Kinetics, Alzheimer’s disease. |
| Issue Date |
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August 2014 |
| Abstract |
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Purpose: Cholinesterase inhibitors are the class of compounds which inhibit cholinesterase enzyme. These are used as drugs for symptomatic treatment of Alzheimer’s disease (AD). The present study, evaluate anti-butrylcholinestease property of ethanolic extract of Shorea robusta de oil cake (DOC).
Method: Ellman’s method was used to determine the butyrylcholinesterase (BuChE) enzyme inhibitory activity by an ethanolic extracts of Shorea robusta de oil cake (DOC).
Results: In present study, Shorea robusta DOC showed concentration dependent BuChE inhibition by an ethanolic extracts of Shorea robusta with maximum inhibition (63.11±0.09%) at 200µg/ml final concentrations. The Lineweaver-Burk plot of an ethanolic extract of Shorea robusta DOC showed mixed non-competitive mode of inhibition.
Conclusion: The anti BuChE enzyme activity exhibited by an ethanolic extracts of Shorea robusta DOC extracts might be used in future for symptomatic treatment of AD. |
| Page(s) |
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480-483 |
| ISSN |
: |
0975-9492 |
| Source |
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Vol. 5, No.8 |
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