ISSN : 0975-9492


Open Access

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Title : Hemolytic activity of different herbal extracts used in Algeria
Authors : Mohammedi Zohra, Atik Fawzia
Keywords : medicinal plants, bioactive compounds, toxicity, erythrocyte, hemolytic activity
Issue Date : August 2014
Abstract :
Purpose: The membrane of erythrocyte can be affected by consumption of bioactive compounds from herbs and medicinal plants. Hemolytic activities of nine extracts from different species on human erythrocytes were investigated. Methods: The toxicity of methanolic extracts of nine plants from arid and sub-arid area on human erythrocytes was measured by in vitro hemolytic assay. The absorbance of hemoglobin release was read by spectrophotometer at 540 nm. Results: our results show that hemolytic activity in all extracts is not more than15% and not significant alteration on erythrocyte membrane was observed at low concentrations while hemolytic activity is concentration-dependent. Hemolytic effect was amplified at increased concentration and it is function of extract. The higher hemolytic activity is showing with extract from the Saharan species Morettia canescens (14.80%). In addition, none hemolytic activity was observed against human erythrocytes with Paronychia chlorothyrsa extract. The present study show that majority of extracts of different plants manifest hemolytic activity < 15%. Conclusion: These results explain that parameters of red blood membrane cell are not altered if therapeutic formulations from these plants are used at low concentration, but a great attention will take with greatest concentrations.
Page(s) : 495-500
ISSN : 0975-9492
Source : Vol. 5, No.8