ISSN : 0975-9492
CODEN : IJPSQQ





INTERNATIONAL JOURNAL OF PHARMA SCIENCES AND RESEARCH


Open Access

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ABSTRACT

Title : BOERHAAVIA DIFFUSA IN CANCER THERAPY AN INSILICO ANALYSIS
Authors : Priya Antony.P, P.A Nazeem
Keywords : Boerhaavia diffusa, Cancer, Phytocompounds, Molecular docking, Bcl-2, Discovery studio 3.5
Issue Date : July 2014
Abstract :
Cancer is leading cause of death worldwide and it is characterized by uncontrolled growth of cells in the body. Apoptosis or programmed cell death plays a major role in normal cell development and tissue homeostasis and cancer cells do lack this property. The Bcl-2 family of proteins regulates apoptotic pathway by the interaction of pro apoptotic and anti apoptotic proteins. They maintain a balance between newly forming cells and old dying cells. Over expressed anti apoptotic Bcl-2 will alter the ratio of pro and anti apoptotic proteins, resulting in the prevention of apoptosis. Elevated levels of apoptosis-inhibitory protein Bcl-2 has frequently been detected in many forms of human cancer. Therefore, Bcl-2 appears to be a relevant target for cancer therapy. Plants have been used for treating various diseases since ancient times. Boerhaavia diffusa is an important medicinal plant used in various human ailments, including cancer, diabetes, hepatoprotective and anti-inflammatory effects. However, most of the reports in traditional medicine are yet to be validated through scientific studies. The present study focuses on identifying phytocompounds in Boerhaavia diffusa having anticancer potential to effectively inhibit the action of Bcl- 2 protein. Insilico docking analysis are well adapted for screening of phytocompounds so as to find the inhibitory or promotive role of potent lead molecules against respective targets. Thirty seven ligands of various confirmations were docked to target protein Bcl-2 using Discovery studio 3.5. The most effective ones were identified through docking score and interaction energy.
Page(s) : 391-396
ISSN : 0975-9492
Source : Vol. 5, No.7