ISSN : 0975-9492


Open Access

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Title : Simple UV spectrophotometric assay of Mefenamic acid
Authors : Dr. Safila Naveed, Fatima Qamar
Keywords : mefenamic acid, assay, UV spectrophotometry
Issue Date : July 2014
Abstract :
Mefenamic acid belongs to non-steroidal antiinflammatory drugs (NSAID).. It is being used widely for the treatment of analgesia. It is also used as antirheumatic and antipyretic drug. Our aim of study is to develop a efficient least time consuming and simple spectrophotometric method for the assay of mefenamic acid. Comparision of assay of three different brands of mefenamic acid (mefnac,ponstan,dolar ) available in public medical store of Karachi, Pakistan has also been done. The assay is based on the ultraviolet UV absorbance maxima at about 288nm wavelength of mefenamic acid, water is used as solvent. A sample of drug was dissolved in water to produce a solution containing mefenamic acid. Similarly, a sample of ground tablets of different brand were dissolved in water and various dilutions were made. The absorbance of sample preparation was measured at 288nm against the solvent blank and the assay was determined by comparing with the absorbance of available brand. Our results reveals that among all the three brands of mefenamic acid (mefnac,ponstan,dolar ) rosulin and rovista shows highest percentage assay 107.5%. xplended and rosubar shows percent assay of 106.25% and 103.75% while rovactor shows lowest value for percentage assay 98.75%.
Page(s) : 364-366
ISSN : 0975-9492
Source : Vol. 5, No.7