|
|
ABSTRACT
| Title |
: |
Preparation of Ibuprofen-loaded Eudragit S100 nanoparticles by Solvent evaporation technique. |
| Authors |
: |
VINEELA CH, KRISHNA SAILAJA K |
| Keywords |
: |
Solvent evaporation, Ibuprofen, Eudragit S-100, drug content, encapsulation efficiency, invitro drug release. |
| Issue Date |
: |
July 2014 |
| Abstract |
: |
Aim: The aim of the present study is to prepare Ibuprofen loaded Eudragit-S100 nanoparticles by means of Solvent evaporation method. Span 80 is used as surfactant. The model drug, Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) commonly used for the relief of symptoms of arthritis, primary dysmenorrheal, alleviating fever and reducing inflammation. It also has an analgesic effect, anti-platelet effect and vasodilation effect. Ibuprofen is available in the form of extended release tablets, chewable tablets, sustained release capsules, liquid filled capsules, syrup and suspension.
Methodology: Solvent evaporation technique was adapted for the preparation of Ibuprofen loaded Eudragit S100 nanoparticles. Preformed polymeric and drug solution was used as internal phase and mineral oil with 1% span 80 is used as external phase and allowed for stirring resulting in the formation of nanoparticles. Parameters like stirring rate, polymer to drug concentration and organic solvent quantity were optimized.
Results and Conclusion: In order to optimize the concentration of drug, polymer and organic solvent, three formulations were prepared by varying the concentration of polymer and solvents. The results obtained were compared. On comparision formulation 3(1:2) was showing particles in nanorange (345nm), higher stability (-26.9mV) and better entrapment efficiency (96.47). Invitro drug release studies were performed for a period of 10hrs and 46.02% of the drug has been released from the formulation.
Conclusion: It was observed that as the polymer ratio increases the release rate is sustained and encapsulation efficiency also increased. |
| Page(s) |
: |
375-384 |
| ISSN |
: |
0975-9492 |
| Source |
: |
Vol. 5, No.7 |
|
Copyright to ENGG Journals Publications
