ISSN : 0975-9492
CODEN : IJPSQQ





INTERNATIONAL JOURNAL OF PHARMA SCIENCES AND RESEARCH


Open Access

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ABSTRACT

Title : Berberine target key enzymes and amino acid inibitiors in AD treatment-----creation from berberine-based structure screening
Authors : Yau Lam
Keywords : -
Issue Date : July 2014
Abstract :
The main components of berberine from coptis have a variety of pharmacological activity include the treatment of neurodegenerative diseases, Alzheimerĺs disease (AD). The principle of berberine is inhibiting the lower activity of enzyme and amino acid to prevent (AD). Enzyme like acetylcholinesterase enzyme (AchE), butyrylcholinesterase enzyme (BchE) and monoamine oxidase (MAO); Amino acid like beta-amyloid (A▀). Unfortunately, the single chemical structures of berberine is no significance to regulation effect. As a part of our consideration, the review paper studies on chemically modified and synthesis from berberine-derivatives. Results show that the structures of (23), (10), (86), (52), and (61) have a potential effect for AchE, BuChE and A▀-amyloid inhibitors for the first time. Especially in (23) and (52) also has better than two western medicine were compared.
Page(s) : 350-363
ISSN : 0975-9492
Source : Vol. 5, No.7