| Abstract |
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The main components of berberine from coptis have a variety of pharmacological activity include the treatment of neurodegenerative diseases, Alzheimer’s disease (AD). The principle of berberine is inhibiting the lower activity of enzyme and amino acid to prevent (AD). Enzyme like acetylcholinesterase enzyme (AchE), butyrylcholinesterase enzyme (BchE) and monoamine oxidase (MAO); Amino acid like beta-amyloid (Aß). Unfortunately, the single chemical structures of berberine is no significance to regulation effect. As a part of our consideration, the review paper studies on chemically modified and synthesis from berberine-derivatives. Results show that the structures of (23), (10), (86), (52), and (61) have a potential effect for AchE, BuChE and Aß-amyloid inhibitors for the first time. Especially in (23) and (52) also has better than two western medicine were compared. |
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