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ABSTRACT
| Title |
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IMPROVED SYNTHESIS OF SUBSTITUTED PYRIMIDIN-2-ONE DERIVATIVES USING MICROWAVE AND ULTRASOUND IRRADIATION |
| Authors |
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Desai Sujit Arun, Bhatia Manish Sudesh, Choudhari Prafulla Balkrishna, Ingale Kundan Bhanudas |
| Keywords |
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Biginelli reaction, pyrimidine, Microwave, Ultrasound. |
| Issue Date |
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June 2014 |
| Abstract |
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Various substituted 4-oxo-2-thioxo tetrahydropyrimidine, 2-oxo dihydropyrimidine, 3,6-disubstituted and 4,5-disubstituted tetrahydropyrimidin-2-one derivatives containing different functional groups have been synthesized under microwave and ultrasound irradiation. The 3,6-disubstituted derivatives were prepared by reacting substituted pyrimidine derivatives synthesized under ultrasound irridation, with ethybromoacetate and product formed was converted to respective hydrazide derivatives, which were further condensed with various aromatic aldehydes. The 4,5-disubstituted tetrahydropyrimidines derivatives were synthesized simply by reacting substituted pyrimidine derivatives synthesized using modified biginelli reaction with various aromatic amines. The IR, 1H NMR and mass spectral data confirmed the structure of the newly synthesized compounds. |
| Page(s) |
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241-248 |
| ISSN |
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0975-9492 |
| Source |
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Vol. 5, No.6 |
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