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ABSTRACT
| Title |
: |
Effect of Cyclophosphamide on Neural Tube Development in Chick Embryos |
| Authors |
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SHABANA SULTANA, MRUDULA CHANDRUPATLA, NAVEENA SWARGAM, ARUNA JYOTHI |
| Keywords |
: |
- |
| Issue Date |
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June 2014 |
| Abstract |
: |
Cyclophosphamide is a nitrogen mustard alkylating agent. CP has potent immunosuppressive properties and issued clinically in a number of autoimmune disorders like Wegener’s granulomatosis, rheumatoid arthritis, nephritic syndrome, systemic lupus erythematous and has also been used to prevent organ rejection after transplantation. In the present study fertilized eggs were administered with cyclophosphamide and the development of neural tube was studied after 21 days. The histological and gross features of neural tube were identified. Cyclophosphamide cytotoxicity results in depression of proliferation of cell activity associated with malformations and embryonic death. Injection of the drug causes depression of mitotic activity by day 2 which produces malformations. |
| Page(s) |
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238-240 |
| ISSN |
: |
0975-9492 |
| Source |
: |
Vol. 5, No.6 |
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