ISSN : 0975-9492


Open Access

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Title : Fixed drug eruption due to metronidazole: a case report
Authors : Dr. Maxilline D. Marak, Dr. (Mrs.) Kalkambe A. Sangma, Dr. (Mrs.) Julie Birdie Wahlang, Dr. Dhriti Kr. Brahma
Keywords : metronidazole, fixed drug eruption
Issue Date : June 2014
Abstract :
Introduction: Metronidazole is commonly used for the treatment of amebiasis, giardiasis and trichomonous vaginitis. Its side effects are relatively frequent and unpleasant, but nonserious. It has the potential to cause fixed drug eruption (FDE).
Case Presentation: This 10 year male boy presented for the itching in some part of the body including an itchy, erythematous oval lesion over the right side of the lower part of anterior abdominal wall. He developed these problems after intake of metronidazole tablet. He was diagnosed to be a case of FDE due to metronidazole. This case of adverse drug reaction (ADR) was “probable” type (Score=7) of reaction based on Naranjo ADR probability scale and severity assessment showed “mild” type (level 2) based on Hartwig et al scale. The offending drug was stopped immediately and managed with deflazacort tablet 12 mg for 10 days and Fusidic acid+Betamethasone cream for topical application.
Discussion: FDE due to metronidazole usually occur within 30 min to 8 hours following its administration and mean length of time from drug intake to the onset of symptoms is approximately 2 hr. Tissue damage in FDE results from the preferential activation of intraepidermal CD8+T cells
Page(s) : 283-285
ISSN : 0975-9492
Source : Vol. 5, No.6