ISSN : 0975-9492
CODEN : IJPSQQ





INTERNATIONAL JOURNAL OF PHARMA SCIENCES AND RESEARCH


Open Access

This website is certified by Health On the Net Foundation. Click to verify.

This site complies with the HONcode standard for trustworthy health information:
verify here.

ABSTRACT

Title : MICROSPHERIC IN-SITU GEL FOR OCULAR DRUG DELIVERY SYSTEM OF BROMFENAC SODIUM
Authors : PRERANA VENGURLEKAR, ASMITA SINGH, SUDHA RATHOD
Keywords : Bromfenac sodium (BNa), micsrospheric in-situ gelling system, egg albumin.
Issue Date : April 2014
Abstract :
Purpose: The aim of the study was to develop a sustained release microspheric in-situ gel for bromfenac sodium (BNa) to be administered through ocular route. It was prepared for the treatment of post-operative cataract surgery. It increases the therapeutic efficiency, reduces dosing frequency and prolonged duration of action. Methods: Albumin microspheres were prepared by protein gelation process and dispersed into in-situ gel, which was prepared by pH triggered method. Result and conclusion: The particle size analysis revealed that all formulations gave particles size in the range of 1-10 Ám which is suitable for ocular administration of formulation. The entrapment efficiency of microspheres was found to be 84.2% and drug release from microspheres were found to be 80.558 % at 24 h. The microspheric in-situ gel of optimized formulation shows drug release of 77.989% at the end of 24 hours. Stability studies were conducted. Hence, it can be concluded that microsphere in-situ gels were a viable alternative to conventional eye drops by providing sustained release of medicaments in the eye.
Page(s) : 179-185
ISSN : 0975-9492
Source : Vol. 5, No.4