ISSN : 0975-9492
CODEN : IJPSQQ





INTERNATIONAL JOURNAL OF PHARMA SCIENCES AND RESEARCH


Open Access

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ABSTRACT

Title : Methanol extract of Ocimum gratissimum leaves modulates the liver and kidney functions in CCl4 - induced hepatotoxicity in albino rats.
Authors : Dr Diwanshu Sharma, Dr Shafiqa Aslam, Dr Rani Walia, Dr P D Gupta
Keywords : Ocimum gratissimum leaves, carbon tetrachloride, methanol extract, hepatotoxicity, enzymes.
Issue Date : February 2014
Abstract :
Ocimum gratissimum is used traditional plant in several disorders due to their excellent antioxidant properties. In a 14 - day study, animals were divided into six groups (A-F) of five rats each. Group A (normal control), group B was given CCl4 only while groups C, D, E and F were given CCl4 with various doses of methanol extract of Ocimum gratissimum leaves (100mg/kg, 200mg/kg, 300mg/kg and 400mg/kg) body weight respectively. Effect of daily intake of methanol extract of Ocimum gratissimum leaves over a period of two weeks on ratsí hepatocellular system was investigated. Standard enzyme assays were conducted for some enzymes of the liver and kidney. From the result, there was relatively no significant difference (p<0.05) in enzyme activity of the groups given the extract and group A in both liver and kidney. It could be inferred therefore, that methanol extract of Ocimum gratissimum leaves could serve as excellent chemotherapeutic agent for prevention of CCl4.
Page(s) : 36-41
ISSN : 0975-9492
Source : Vol. 5, No.2