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ABSTRACT
| Title |
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Antipyretic Activity of Abutilon mauritianum (Jacq.) Roots in Wistar Rats |
| Authors |
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Tosan Charles Akapa, Adeoti Olayinka Kehinde, Ojewuyi Oluwayemisi Beatrice, Olayemi Joseph Olajide |
| Keywords |
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Abutilon mauritianum, brewer’s yeast, lipopolysaccharide, paracetamol. |
| Issue Date |
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February 2014 |
| Abstract |
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Purpose: Ethanolic extract of Abutilon mauritianum roots (EEAMR) was evaluated for its antipyretic activity. Methodology: The antipyretic activity was done using changes in rectal temperature influenced by brewer’s yeast (10mg/kg) and lipopolysaccharide (0.3µg/kg) induced pyrexia in rats. Forty-two male wistar albino rats weighing 160.39 ± 9.23g were used for the study and randomized into seven groups of six rats each. In the first experiment, all the rats were induced with pyresis using 10 mg/kg body weight of brewer’s yeast subcutaneously. Group I (negative control) was given 0.5 ml of distilled water. Rats in groups II (positive control), III and IV were given 100mg/kg p.o paracetamol (PCM), 150 and 300 mg/kg p.o of EEAMR respectively. In the second experiment, the rats were induced with pyresis using 0.3 µg/kg body weight of lipopolysaccharide (LPS) intravenously. Group I (negative control) was given 0.5 ml of distilled water while groups II (positive control) and III were given 100mg/kg p.o paracetamol (PCM) and 600 mg/kg p.o of EEAMR respectively. Results: The extract significantly lowered (P<0.05) the elevated rectal temperature in the brewer yeast and lipopolysaccharide induced pyretic models which was also dose dependent. The antipyretic effect of the extract was comparable to the standard antipyretic drug paracetamol (PCM).
Conclusion: This revealed that the extract has an antipyretic activity and supports its use in managing fever. |
| Page(s) |
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42-46 |
| ISSN |
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0975-9492 |
| Source |
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Vol. 5, No.2 |
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