ISSN : 0975-9492


Open Access

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Title : Formulation And Evaluation Of Compression Coated Tablets Of Cefpodoxime Proxetil
Authors : Ms. Nandini.D.Banerjee, Mrs. Sushma R. Singh
Keywords : Floating tablet, Fast disintegrating tablet, Factorial design, Xanthan gum, Hydroxypropyl methyl cellulose.
Issue Date : July 2013
Abstract :
The purpose of this study was to formulate Cefpodoxime Proxetil compression-coated tablets for gastroretentive drug delivery. In this the core tablet is formulated to be retained in the stomach for a period of approximately 12 hrs using different polymer blend. The core tablet has half the amount of the drug and the rest of the drug in the coating layer. This outer layer is so formulated to release its drug content in a period of 15mins so as to achieve the initial burst release and then after 2 hours as the plasma concentration of the drug decreases then the core layer starts releasing its drug content so that the plasma concentration of the drug is maintained in the therapeutic window for the duration of 12 hrs. Thus the dosing interval is increased from 4 hrs to 12hrs. The batches are optimized using the factorial designing. Also the formulation is evaluated for its release profile and compared with the other standard release profiles.
Page(s) : 104-112
ISSN : 0975-9492
Source : Vol. 4, No.7