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ABSTRACT
| Title |
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EXTRACTIVE SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF MEROPENEM PURE AND IN MARKETED FORMULATIONS USING ACIDIC DYES (BTB &BCP) |
| Authors |
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Venkateswararao L, Vardhan S.V.M, Rambabu.C |
| Keywords |
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Meropenem, Ion association complex |
| Issue Date |
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June 2013 |
| Abstract |
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Two simple, sensitive and extractive spectrophotometric methods have been developed and validated for the determination of meropenem in pure and in marketed formulations. The proposed methods were based on the formation of ion-pair complex between meropenem and Bromothymol Blue and Bromocresol Purple at pH 3.0 ± 0.01 which was extracted into chloroform and the absorbance of yellow ion-pair complex was measured at 420nm and 418nm repectively. Under optimized conditions, the Beer’s law was obeyed over 10- 50µg/mL for BTB and BCP and 12.5-62.5µg/mL respectively, and the corresponding molar absorptivity values were 1.018x103L/mol/cm and 1.43x103L /mol/cm. The Sandell sensitivity values of 0.6548 and 0.7854µg/cm2 for BTB and BCP respectively. Application of the proposed methods to commercial formulations of meropenem was validated according to ICH guidelines. |
| Page(s) |
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100-103 |
| ISSN |
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0975-9492 |
| Source |
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Vol. 4, No.6 |
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