ISSN : 0975-9492
CODEN : IJPSQQ





INTERNATIONAL JOURNAL OF PHARMA SCIENCES AND RESEARCH


Open Access

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ABSTRACT

Title : Effect of Glycowithanolides on Fucose Content in Salivary Glands of Aged Mice
Authors : R. N. Mote, M. M. Pillai
Keywords : antioxidants/ D-galactose/ fucose/ glycowithanolides/ salivary glands
Issue Date : March 2013
Abstract :
Glycowithanolides (WSG) is the extract of Withania somnifera leaves was tested to find its effect on fucose content in salivary glands of D-galactose(Dg) stressed adult and old male mice (Mus musculus). Adult and old male mice were divided in to protective group and curative group. Both the groups were further divided into four batches viz. 1st is the control batch received 0.5 ml 0.9 % saline per day for 20 and 40 days for protective and curative group respectively. Mice from 2nd, 3rd and 4th batches of protective group received 0.5 ml D-galactose (Dg), Dg+centrophenoxine(CPH) and D-galactose (Dg) + (WSG) respectively for 20 days. Mice from 2nd, 3rd and 4th batches of curative group received 0.5 ml D-galactose (Dg) for 20 days then followed by 0.5ml saline, centrophenoxine and WSG alone for further 20 days respectively. Fucose content (g/mg proteins) in salivary glands was estimated. In Dgalactose stressed adult and old mice it was decreased significantly, but restored by the treatment of WSG and centrophenoxine. The restoration was not exactly up to the normal level but was near to the normal level in adult. In D-galactose stressed old mice there was restoration in fucose content but it was not like that of adult. Restoration was significantly higher in WSG treatment. Thus WSG can be used as a powerful natural antioxidant and antistresser.
Page(s) : 57-65
ISSN : 0975-9492
Source : Vol. 4, No.3