ISSN : 0975-9492
CODEN : IJPSQQ





INTERNATIONAL JOURNAL OF PHARMA SCIENCES AND RESEARCH


Open Access

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ABSTRACT

Title : Synthesis and in Vitro Cytotoxic Activity of Some Novel -Carbolines bearing pyrrol-2- one moiety
Authors : S.Senthil Kumar, M.Mariappan
Keywords : Synthesis, -carbolines, Bischler-Napieralski reaction, cytotoxic activity, MTT assay.
Issue Date : March 2013
Abstract :
-carboline are reported to have anticancer activities on cultured cancer cell lines.To further enhance the cytotoxic potency, a series of novel 5-substituted -carboline derivatives have been synthesized from 5-Amino-4-(1H-indol-3-yl)-1,3-dihydro-pyrrol-2-one via Bischler-Napieralski reaction . The newly synthesized compounds were characterized by spectral studies. All compounds were evaluated for in vitro cytotoxic activity against three human cancer cell lines(HeLa,HepG2 and A431 )using MTT assay.
Page(s) : 47-53
ISSN : 0975-9492
Source : Vol. 4, No.3