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ABSTRACT
| Title |
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Synthesis and in Vitro Cytotoxic Activity of Some Novel ß-Carbolines bearing pyrrol-2- one moiety |
| Authors |
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S.Senthil Kumar, M.Mariappan |
| Keywords |
: |
Synthesis, ß-carbolines, Bischler-Napieralski reaction, cytotoxic activity, MTT assay. |
| Issue Date |
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March 2013 |
| Abstract |
: |
ß-carboline are reported to have anticancer activities on cultured cancer cell lines.To further enhance the cytotoxic potency, a series of novel 5-substituted ß-carboline derivatives have been synthesized from 5-Amino-4-(1H-indol-3-yl)-1,3-dihydro-pyrrol-2-one via Bischler-Napieralski reaction . The newly synthesized compounds were characterized by spectral studies. All compounds were evaluated for in vitro cytotoxic activity against three human cancer cell lines(HeLa,HepG2 and A431 )using MTT assay. |
| Page(s) |
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47-53 |
| ISSN |
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0975-9492 |
| Source |
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Vol. 4, No.3 |
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