ISSN : 0975-9492
CODEN : IJPSQQ





INTERNATIONAL JOURNAL OF PHARMA SCIENCES AND RESEARCH


Open Access

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ABSTRACT

Title : «Evaluation of the anti-icterus effect of crude powdered leaf of Argemone mexicana L. (Papaveraceae) against CCl4-induced liver injury in rats».
Authors : T.S. SOURABIE, N. OUEDRAOGO, W.R. SAWADOGO, N. YOUGBARE, J.B. NIKIEMA, I.P. GUISSOU, O. G. NACOULMA
Keywords : argemone mexicana, crude leaf powder, anti-icterus effect.
Issue Date : October 2012
Abstract :
Leaves of Argemone mexicana L. (Papaveraceae) are used in the folk medicine of Burkina Faso (West Africa) to treat a variety of illness. Aqueous decoction of the drug is indicated in the treatment of malaria fever, abdominal pains, and jaundice. A preliminary study led by the authors showed a good anti-icterus (hepatoprotective) activity of leaves extracts on intoxicated Wistar rats. The aim of the present investigation was to evaluate the anti-icterus activity of crude leaf powder against CCl4 induced hepatotoxicity in rats. Liver functions were assessed by the activities of liver marker enzymes, ASAT/GOT, ALAT/GPT, ALP, Total Bilirubin (TBIL) and Direct Bilirubin (DBIL). A crude powdered leaf suspended in acacia gum solution (2% p/w) was administered orally to the animal at doses of 125, 250 and 500 mg/kg attenuated significantly (p<0,05) the elevation of serum enzymes level and bilirubin (total and direct) if compared to the CCl4 treated groups. Silymarin (100 mg/kg, p.o.), a known antihepatoprotective drug was used as reference. The results showed a dose-dependent anti-hepatotoxic effect against liver injury induced by CCl4 in rats. These findings give an opportunity for a future elaboration of galenic formulation as phytomedicament.
Page(s) : 491-496
ISSN : 0975-9492
Source : Vol. 3, No.10