ISSN : 0975-9492


Open Access

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Title : Potent in vitro Cytotoxic Effect of Gmelina arborea Roxb. (Verbenaceae) on Three Human Cancer Cell lines
Authors : David Punitha, Angamuthu Thandavamoorthy, Karuppanan Arumugasamy, Uthaman Danya, Madathupatti Ramanathan Udhayasankar, Thimmayan Baluprakash, Sreenivasapuram Natarajan Suresh
Keywords : Gmelina arborea, Leaf extract, COLO 201, HT-29, TE-2, MTT assay.
Issue Date : April 2012
Abstract :
Cancer is one of the most common devastating disease affecting millions of people per year. It has been estimated as the second leading cause of death in humans. In the present study, the cytotoxicity of ethanolic leaf extracts of Gmelina arborea (Verbenaceae) was tested against Colon cancer (COLO 201), Gastric cancer (HT-29) and Human oesophagel cancer (TE-2) cell lines using the thiazolyl blue test (MTT) assay. Ethanolic leaf extracts of G. arborea was exhibited a prominent inhibitory effect against COLO 201 (IC 50- 200.15 mg/ml), HT-29 (IC 50-120.32 mg/ml) and TE-2 (IC 50- 160.05mg/ml) under in vitro condition. From the results it could be found that G. arborea ethanolic leaf extract has potent in vitro cytotoxic activity.
Page(s) : 357-363
ISSN : 0975-9492
Source : Vol. 3, No.4