ISSN : 0975-9492


Open Access

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Title : Effects of Ethanolic Root Bark Extract of Chrysophyllum albidum on Serum Superoxide Dismutase, Catalase and Malondialdehyde in Rat
Authors : Onyeka C.A, Aligwekwe A.U, Nwakanma A.A, Bakare A.A, Ofoego U.C
Keywords : Chrysophyllum albidum, superoxide dismutase, catalase, MDA
Issue Date : March 2012
Abstract :
Purpose: The ethanolic root bark of Chrysophyllum albidum were evaluated for their effect on antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT) and lipid peroxidation (malondialdehyde) activities in rats.
Methods: Eighteen male Wister rats weighing 100-200g were divided into three groups of six animals each. Two treated groups received a daily dose of ethanolic root bark of Chrysophyllum albidum at 100mg/kg and 200mg/kg body weight respectively via gastric gavage, while equal volume of normal saline was administered to the control group for 3 weeks.
Result: All the in vitro models showed dose dependent activity. However the weight gain was dose related with a decrease activity of SOD and CAT (p<0.05) in 100mg/kg treated rats, indicating an altered oxidative statues in the animals but as the dose increase, SOD and CAT activity increase. MDA concentration was reduced (p<0.05) in the treated rats.
Conclusion: The result suggests that the root bark extract of C. albidum has evidence of scavenging and antiperodative properties.
Page(s) : 348-352
ISSN : 0975-9492
Source : Vol. 3, No.3