ISSN : 0975-9492
CODEN : IJPSQQ





INTERNATIONAL JOURNAL OF PHARMA SCIENCES AND RESEARCH


Open Access

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ABSTRACT

Title : Identification of a-Glucosidase Inhibitors From Psidium guajava Leaves and Syzygium cumini Linn. Seeds
Authors : Kathirvel Alagesan*, Prabhakar Thennarasu, Vinoth Kumar, Sadasivam Sankarnarayanan, Thayumanavan Balsamy
Keywords : Diabetes, a-glucosidase, Medicinal plants, P.guajava, Reversible inhibitor, S.cumini
Issue Date : February 2012
Abstract :
We screened for a-glucosidase inhibitors from 12 traditional medicinal plants used for the treatment of diabetes. Potent a-glucosidase inhibitory activity was found in aqueous extract of Psidium guajava leaves and Syzygium cumini Linn seed extract. Active principles inhibiting a-glucosidase were isolated and identified as apigenin 7-O-glucoside in the S.cumini Linn seed extract and Dihydro-3,3,4,5,7 pentahydroxyflavone glycoside in P.guajava leaf extract through FT-IR and LC-MS. The inhibitor present in both P.guajava leaves and S.cumini Linn seed extract was found to be reversible in nature.
Page(s) : 316-322
ISSN : 0975-9492
Source : Vol. 3, No.2