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ABSTRACT
| Title |
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OPTIMISATION AND CHARACETRISATION OF CHITOSAN MICROSPHERES OF ACECLOFENAC |
| Authors |
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M. Mothilal*, M. Nagalakshmi, Swati P.S., Damodharan N., Manimaran.V, Lakshmi K.S. |
| Keywords |
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Aceclofenac, Chitosan, Box-Behnken experimental design, microspheres |
| Issue Date |
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February 2012 |
| Abstract |
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Purpose: The purpose of this study was to optimize and characterize the controlled release microspheres of Aceclofenac using “Box-Behnken experimental design”. The microspheres were prepared by using the natural polymer chitosan in different ratios with glutraldehyde as the cross linking agent. Method: The microspheres were prepared by ionic cross linking technique. The microspheres were evaluated for particle size, drug content, drug loading efficiency, in vitro drug release surface morphology. Results and Conclusions: The particle size of the prepared microspheres was between 3 to 800µm in diameter. In conclusion NSAID controlled release delivery system utilizing natural polymer i.e; chitosan was successfully developed. Further parameters for dosage form designing can be identified for optimum formulation in terms of desirable long term stability and to study the therapeutic effects of these particles in vivo. |
| Page(s) |
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305-315 |
| ISSN |
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0975-9492 |
| Source |
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Vol. 3, No.2 |
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