ISSN : 0975-9492


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Title : Crosslink Polyacrilic Resin Based Levocetirizine Melt-In-Mouth Tablets
Authors : Subhakanta Kanungo, Saikh Mahammed Ajhar Ali, Amalesh Samanta, Saikh Mahammed Athar Alli
Keywords : Melt-in-mouth tablet, levocetirizine hydrochloride, pharmacopoeial, specification.
Issue Date : November 2011
Abstract :
Purpose of undertaken project was to formulate crosslink polyacrilic resin based, technologically optimised, melt-in-mouth tablet (MIMT) containing 5 mg of Levocetirizine Dihydrochloride that was intended to disintegrate rapidly in the oral cavity so as to form a stabilised dispersion and possessing adequate physicochemical stability. Different grades of crosslink polyacrilic resin were utilised to prepare MIMTs; employing complexation technique; and using additives like Mannitol DC, Ac-di-sol, Avicel-pH 112, Tusil pinapple, Saccharine sodium, Aerosil and Magnesium stearate. MIMTs were evaluated for compliance to pharmacopoeial specifications. From in-vitro dissolution profile plot, values for the kinetic constant and the regression coefficient of model-dependent approaches were determined to find the best fit release kinetic model while from in-vitro dissolution profile data the difference factor, the similarity factor and the indices of rescigno of model-independent approaches were determined for comparing pair of in-vitro dissolution profiles. MIMTs of levocetirizine was successfully developed complying pharmacopoeial specifications, with adequate stability at room temperature.
Page(s) : 196-204
ISSN : 0975-9492
Source : Vol. 2, No.11