ISSN : 0975-9492
CODEN : IJPSQQ





INTERNATIONAL JOURNAL OF PHARMA SCIENCES AND RESEARCH


Open Access

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ABSTRACT

Title : Immunomodulatory effect of methanol extract of Solanum xanthocarpum fruits
Authors : 1Rokeya Sultana, Salma Khanam, Kshama Devi
Keywords : Solanum xanthocarpum, methanol extract, Immunomodulatory activity, Cyclophosphamide, immunopotentiation
Issue Date : February 2011
Abstract :
Purpose : To study the immunomodulatory activity of methanol extracts of fruits of Solanum xanthocarpum (Solanaceae) on Swiss albino mice.
Methods
Model -Cyclophosphamide induced immunosuppression model
Animal used - Swiss albino mice.
Dose Cyclophosphamide-30mg/kg body weight, i.p route.
Extract-100mg/kg body weight, oral route.
The extent of protection against immunosuppression caused by Cyclophosphsmide was evaluated after 14 days of drug administration, by estimating hematological parameter and neutrophil adhesion test.
Results
Methanol extracts of fruits of Solanum xanthocarpum showed pronounced immunoprotective activity by increasing the depleted levels of total WBC count and RBC, % Hb, and % neutrophils adhesion.
Conclusions
The extract was found to be effective immunomodulatory agents.
Page(s) : 93-97
ISSN : 0975-9492
Source : Vol. 2, No.2