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ABSTRACT
| Title |
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SPECTROPHOTOMETRIC DETERMINATION OF ORNIDAZOLE IN PURE AND PHARMACEUTICAL FORMULATIONS |
| Authors |
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P.Tulasamma, V.Govind, P. Venkateswarlu |
| Keywords |
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Ornidazole; Ferric Chloride; Potassium ferricyanide; 2, 2-Bipyridyl; Zinc powder, Spectrophotometry; |
| Issue Date |
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January 2011 |
| Abstract |
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Two simple, sensitive, rapid and reproducible spectrophotometric methods have been developed for the determination of ornidazole in pure form or in their tablets. The proposed methods are based on the reduction of the nitro group to amino group of the drug. The reduction of Ornidazole is carried out with Zn powder and 5N HCl at room temperature in methanol. The resulting amine was then subjected to two methods. Method A is based on the extraction product with Potassium ferricynide - Fe (III) reagent to form bluish green colored choromogen exhibiting an absorption maximum at 570 nm with appearent molar absorptivity of 0.395x104 L mol-1 cm-1 and obeyed Beer’s law in the concentration range 5-55 µg/ml. Method B is based on the oxidation followed by complex with 2, 2-Bipyridyl – Fe (III) to from orange colored chromogen exhibiting absorption maxima 510 nm with apparent molarabsorptivity of 0.710x104 L mol-1 cm-1 and obeyed Beer’s law in the concentration range 5-50 µg/ml .The sandell’s sensitivity, limit of detection (LOD) and quantification (LOQ) values have been reported for both the methods. The accuracy and precision of the methods were evaluated on intraday and inter- day basis. The methods were by the common pharmaceutical adjuvants. The reliability and the performance of the proposed methods are established through recovery studies. |
| Page(s) |
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44-48 |
| ISSN |
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0975-9492 |
| Source |
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Vol. 2, No.1 |
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