ISSN : 0975-9492


Open Access

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Title : Rapid determination of Ziprasidone and Buclizine Hydrochloride in pharmaceutical formulations (Tablets) by simple spectrophotometric method
Authors : Medikondu Kishorea, Y.Hanumantha Rao, M.Janardhan
Keywords : Ziprasidone hydrochloride, Buclizine hydrochloride, spectrophotometric method, Ion Association complex, statistical analysis, drug recovery studies.
Issue Date : November 2010
Abstract :
A simple, sensitive, selective and accurate spectrophotometric method for the determination of Ziprasidone (ZPD) hydrochloride and Buclizine (BUCZ) hydrochloride in bulk drug and pharmaceutical formulations (tablets) has been described. This method is based on the formation of ion-association complex of drug with Alizarin red S (ARS) to form pale pink colored chromogen exhibiting max 420 nm respectively. The results of analysis for this method have been validated statistically and by recovery studies. The results are compared with those obtained using UV spectrophotometric method in isopropyl alcohol at 229 nm (ZPD), and in Chloroform at 272 nm (BUCZ). The method is simple and sensitive and has been applied successfully to the analysis of laboratory-made tablets without any interference from the tablet excipients.
Page(s) : 438-444
ISSN : 0975-9492
Source : Vol. 1, No.10