ISSN : 0975-9492
CODEN : IJPSQQ





INTERNATIONAL JOURNAL OF PHARMA SCIENCES AND RESEARCH


Open Access

This website is certified by Health On the Net Foundation. Click to verify.

This site complies with the HONcode standard for trustworthy health information:
verify here.

ABSTRACT

Title : RIBOSWITCHES: CLASSIFICATION, FUNCTION and INSILICO APPROACH.
Authors : MEHTA NEEL B., PRASHANNA BALAJI
Keywords : Cis-acting elements, Gene expression, Riboswitches and UnTranslated Region (UTR)
Issue Date : October 2010
Abstract :
Extensive study on RNA in recent times has resulted into discovering a type of genetic regulatory elements which are found in number of organism and undergoes different folding and functional process leading to repression of gene expression, termed as Riboswitches. Riboswitches are present in three kingdoms of life and have been identified in the genomes of plants, archaea and fungi. They are highly structured cis-acting elements located in the 5-UnTranslated Region (UTR) of mRNA in the organism and the most important characteristic of riboswitches is that they fold into complex three dimensional structures to serve as precise receptors for their target molecules, organized around helical junctions with varying degrees of complexity. The combinations of computational and molecular approaches have significantly led to the identification of an increasing number of existing and novel riboswitches. In this paper we have classified all main types of riboswitches according to their functional characteristics and various tools (software) are mentioned to identify them through in silico approach.
Page(s) : 409-420
ISSN : 0975-9492
Source : Vol. 1, No.9