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ABSTRACT
| Title |
: |
Biochemical Effects of Plumbagin on Fibrosarcoma Induced Rats |
| Authors |
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P.Jayamathi, Vishnupriya V, Surapaneni Krishna Mohan |
| Keywords |
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Plumbagin, lipid profile, fibrosarcoma, pathophysiological enzymes |
| Issue Date |
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September 2010 |
| Abstract |
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Natural products from plants are used for treating a number of diseases. Many of the pharmacological principles of the currently used anticancer agents have been initially isolated from plants. Plumbagin, a napthaquinone derivative from Plumbago zeylanica and has been claimed to possess antitumor effect. The tumor weight was found to be reduced in methylcholanthrene induced fibrosarcoma rats after plumbagin treatment. Elevated levels of proteins, lipid profile and also in the activities of pathophysiological enzymes such as gamma glutamyl trans peptidase (GGT), lactate dehydrogenase (LDH), glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), in plasma, liver and kidney extracts of fibrosarcoma rats decreased significantly after Plumbagin treatment. These observations clearly suggested the antitumor potency of plumbagin in experimentally induced fibrosarcoma in rats. |
| Page(s) |
: |
320-325 |
| ISSN |
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0975-9492 |
| Source |
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Vol. 1, No.8 |
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