ISSN : 0975-9492
CODEN : IJPSQQ





INTERNATIONAL JOURNAL OF PHARMA SCIENCES AND RESEARCH


Open Access

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ABSTRACT

Title : DESIGN AND EVALUATION OF COST EFFECTIVE ORODISPERSIBLE TABLETS OF DIETHYLCARBAMAZINE CITRATE BY EFFERVESCENT METHOD
Authors : B.K.Manjunatha, Amit.R.Rupani, Priyanka priyadarshini, Kusum Paul
Keywords : In silico study, Pterocarpus santalinus, active constituents, HBx Protein.
Issue Date : August 2010
Abstract :
Review of the literature revealed that, many compounds have been isolated from P.santalinus but there is no report of screening its potency in protecting CCl4 induced liver damage. Hence in the present study an attempt has been made to study the hepatoprotective potency of the active constituents in P.santalinus through in silico methods. Lipenskiís Rule of Five was applied on all the compounds to evaluate their drug likeness and pharmacological properties. Only the compounds satisfying the Lipenskiís criteria were considered for further computational operations. Compounds that cleared the Lipenskiís barrier were prepared for docking studies by their energy minimization in Marvin Sketch. HBx protein of hepatitis B virus served as a target (receptor) for docking studies. Its structure was retrieved from PDB (ID:3I7H). Energy minimized compounds were subjected to receptor-ligand interaction study using Hex docking tool. Based on the docking scores of energy minimized compounds it was concluded that pterocarpol and cryptomeridiol required minimum energy to bind to HBx. ADME-TOX analysis of these compounds showed that their AMES test value was significantly lower than some of the commercially and widely used drugs to treat Hepatisis. Hence these compounds hold good prospective of being used as medicine that targets HBx for hepatitis treatment.
Page(s) : 265-270
ISSN : 0975-9492
Source : Vol. 1, No.7