ISSN : 0975-9492
CODEN : IJPSQQ





INTERNATIONAL JOURNAL OF PHARMA SCIENCES AND RESEARCH


Open Access

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ABSTRACT

Title : TREATMENT OF RHEUMATOID ARTHRITIS BY A "TOLEROGENIC VACCINATION A" USING siRNA MODIFIED DENDRITIC CELLS
Authors : B.Sai Mrudula, N.K. Durga Devi, B.Radha Madhavi, M.Madhu Babu, V.L.Annapurna
Keywords : RA-Rheumatoid arthritis; DC-Dendritic cells; APCs-Antigen presenting cells; MHCmajor histocompatibility complex; IL-Interleukin; siRNA-Small interfering RNA; Tolerogenic Vaccination.
Issue Date : June 2010
Abstract :
The immune system is a complex organization of cells and antibodies designed normally to seek and destroy invaders of the body particularly infections. Rheumatoid arthritis is an auto immune disease that mistakenly attacks our own immune system and damage tissues around joints, tendons, ligaments and muscles by means of T-cell differentiation.
Dendritic cells are main important APCs .These cells on maturation combines with MHC molecules and co-receptors like CD-80, CD-40 activates T-cells and B-cells. This main action is regulated by IL-12gene in dendritic cells. Tolerogenic vaccination signifies exotic tool that is launched in to humans or domestic animals with an intention to enroot immunity and to generate immunological tolerance that is condition marked by stolidity to a specific antigen. Here in this critique we have cited applicability of RNA modified DC in treatment of Rheumatoid arthritis. By using the method of RNA interference using siRNAIL12 treated DC we can treat RA by decreasing T-cell responses towards our own cells.
Page(s) : 243-247
ISSN : 0975-9492
Source : Vol. 1, No.5