ISSN : 0975-9492
CODEN : IJPSQQ





INTERNATIONAL JOURNAL OF PHARMA SCIENCES AND RESEARCH


Open Access

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ABSTRACT

Title : SPECTROPHOTOMETRIC ESTIMATION OF MELOXICAM IN BULK AND ITS PHARMACEUTICAL FORMULATIONS
Authors : B.DHANDAPANI, S.ESWARA MURALI, N. SUSRUTHA, RAMA SWETHA, S K. SONIA RANI, T. SARATH BABU, G.V. SEETHARAMANJANEYULU, R.V.CELESTIN BABOO
Keywords : Meloxicam, Uv-Spectrophotometry, Ferric chloride and Hydrotropic agent
Issue Date : May 2010
Abstract :
Three simple, accurate, rapid and sensitive methods developed for the determination of meloxicam in bulk drug and in its tablets by UV Spectroscopy (Method - A), Visible (Method -B) and Hydrotropic method (Method - C). In Method A meloxicam estimated at 269 nm using 0.1M NaOH as a solvent. The linearity was observed in the concentration range of 5 30 g/ml with correlation co efficient of 0.9995. In Method B 0.1M NaOH solution using as a solvent and 5% ferric chloride used as a chromogenic agent and the resulting green colour chromogen was measured at 476 nm in the linearity range and correlation co -efficient of 50 250 g/ml and 0.9986. In Method C 10% trisodium citrate solution used as a hydrotropic agent to dissolve the meloxicam which is water insoluble, and it is estimated at 269 nm with the linearity range and correlation co -efficient of 5 30 g/ml and 0.9987. The result of analysis for all the methods was validated statistically and by recovery studies.
Page(s) : 217-221
ISSN : 0975-9492
Source : Vol. 1, No.4