ISSN : 0975-9492
CODEN : IJPSQQ





INTERNATIONAL JOURNAL OF PHARMA SCIENCES AND RESEARCH


Open Access

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ABSTRACT

Title : Spectrophotometric Determination for Nitro-Imidazole Derivative Ornidazole
Authors : Mr. T. Ramanji reddy, Dr. D. Dachinamoorthi, Dr. K.B. Chandra sekhar
Keywords : -
Issue Date : April 2010
Abstract :
Two simple, sensitive, accurate, rapid spectrophotometric methods have been developed for the estimation of Ornidazole in parentaral dosage forms. Method A is based on the reaction of Ornidazole with PDAB, in presence of zinc dust and acidic environment, giving a orange color chromogen, which shows maximum absorbance at 390 nm against reagent blank, while method B is based on the reaction with Bromo phenol blue, in zinc dust and acidic environment absorbance at 430 nm. Beers law was obeyed in the concentration range of 25-162.5 g/ml in method A, and 5-20 g/ml in method B. Results of the analysis were validated statistically and by recovery studies.
Page(s) : 199-202
ISSN : 0975-9492
Source : Vol. 1, No.3