ISSN : 0975-9492
CODEN : IJPSQQ





INTERNATIONAL JOURNAL OF PHARMA SCIENCES AND RESEARCH


Open Access

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ABSTRACT

Title : Synthesis, characterization and antibacterial activity of various substituted oxadiazolylpyrazolinyl/isoxazolinylcoumarin derivatives.
Authors : Hemlata Kaur, Sunil Kumar, Indu Singh, Ashok Kumar
Keywords : Substitutedcoumarin, Oxadiazolylcoumarins, Pyrazolinylcoumarins, Isoxazolinylcoumarins, Antibacterial activity, Acute toxicity.
Issue Date : February 2010
Abstract :
A series of 7-un/substituted-2-spiro-[5-((1-acetyl-5-(substitutedphenyl)amino)-3-(1-acetyl-5-(substitutedphenyl)) pyazolin-3-yl)-1,3,4-oxadiazol-2-yl]coumarins (4a-4h) and 7-un/substituted-2-spiro-2-[(-5- (substitutedphenyl)amino-4-(5-(substitutedphenyl))pyazolin-3-yl)-1,3,4-oxadiazol-2-yl]coumarins (5a-5h) by the reaction of 7-un/substituted-2-spiro-(3-substitutedarylidinyl chalconyl)-5-(substitutedarylidinylaminochalconyl)-oxadiazol-2-yl)coumarins (3a-3h) with hydrazine hydrate and hydroxyl amine respectively. All the newly synthesized compounds were screened for their antibacterial activity against K. pneumoniae, S. aureus, E. coli and B. sublitis and were compared with the standard drug ciprofloxacin. The most potent antibacterial compound of this series was 4g. Structure of all the compounds were established by the elemental (C, H, N) and spectral (IR, 1H NMR and mass) analysis.
Page(s) : 58-65
ISSN : 0975-9492
Source : Vol. 1, No.1