ISSN : 0975-9492
CODEN : IJPSQQ





INTERNATIONAL JOURNAL OF PHARMA SCIENCES AND RESEARCH


Open Access

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ABSTRACT

Title : Inhibition efficiency of urine towards stone forming minerals.
Authors : Dr. Seema Jawalekar, Dr. V.T.Survey, Dr. Anil K. Bhutey
Keywords : kidney stone, promoters, inhibitors, hypocitraturia, hyperoxaluria, Crystallization.
Issue Date : February 2010
Abstract :
Urine specimens were collected from 100 normal individuals and 100 kidney stone patients and analysed spectrophotometrically for common stone promoters like oxalate, calcium, uric acid and phosphate and stone inhibitors like citrate and magnesium. Inhibition efficiency by these inhibitors exiting in urine samples towards the mineralisation of urinary stone forming minerals like calcium oxalate ,phosphate or carbonate has been studied in an experimental model. The results were presented as mean Ī SD, studentís t test was used for statistical analysis. Hypocitraturia and hyperoxaluria were the common abnormalities in the stone formers. Kidney stone patients had significantly higher urinary oxalate, calcium and uric acid and lower phosphate than normal individuals. The efficiency is markedly higher for phosphate, carbonate and urates by healthy urine samples.For the stubborn mineral oxalate has low inhibition efficiency. The urine of stone formers show very little inhibition. This implies that inhibition of crystal growth is proportional to the concentration of inhibitory factor present.
Page(s) : 23-27
ISSN : 0975-9492
Source : Vol. 1, No.1