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ABSTRACT
| Title |
: |
DEVELOPMENT OF UV-VISIBLE SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF DASATINIB IN PHARMACEUTICAL FORMULATION AND BIOLOGICAL SAMPLES |
| Authors |
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B. Ramachandra, P.Suguna, K.Sivarami Reddy, N.V.S.Naidu |
| Keywords |
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Dasatinib, UV-Visible spectrophotometric, Method development, pharmaceutical formulation and biological samples. |
| Issue Date |
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February 2015 |
| Abstract |
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A simple, economical, accurate, precise and reproducible UV-Visible spectrophotometric method for the routine estimation of dasatinib has been developed. The method is based on the formation of a bluish green colored complex by dasatinib in presence of MBTH reagent. The developed colored complex showed ?max at 630 nm. Beer�s law in the concentration range of 10 to 60 �g/ ml. Results of analysis were authenticated statistically as well as by recovery studies, which gave mean recovery between 99 to 100%. The method was successful in determining dasatinib in pharmaceutical formulation and biological samples, with an average recovery between 99 to 100 % respectively. The proposed method could find application to product development scientists in ongoing research; as well provide an additional tool for routine analysis of dasatinib. |
| Page(s) |
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293-303 |
| ISSN |
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0975-9492 |
| Source |
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Vol. 6, No.2 |
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