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ABSTRACT
| Title |
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Methanol extract of Ocimum gratissimum leaves modulates the liver and kidney functions in CCl4 - induced hepatotoxicity in albino rats. |
| Authors |
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Dr Diwanshu Sharma, Dr Shafiqa Aslam, Dr Rani Walia, Dr P D Gupta |
| Keywords |
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Ocimum gratissimum leaves, carbon tetrachloride, methanol extract, hepatotoxicity, enzymes. |
| Issue Date |
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February 2014 |
| Abstract |
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Ocimum gratissimum is used traditional plant in several disorders due to their excellent antioxidant properties. In a 14 - day study, animals were divided into six groups (A-F) of five rats each. Group A (normal control), group B was given CCl4 only while groups C, D, E and F were given CCl4 with various doses of methanol extract of Ocimum gratissimum leaves (100mg/kg, 200mg/kg, 300mg/kg and 400mg/kg) body weight respectively. Effect of daily intake of methanol extract of Ocimum gratissimum leaves over a period of two weeks on rats� hepatocellular system was investigated. Standard enzyme assays were conducted for some enzymes of the liver and kidney. From the result, there was relatively no significant difference (p<0.05) in enzyme activity of the groups given the extract and group A in both liver and kidney. It could be inferred therefore, that methanol extract of Ocimum gratissimum leaves could serve as excellent chemotherapeutic agent for prevention of CCl4. |
| Page(s) |
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36-41 |
| ISSN |
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0975-9492 |
| Source |
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Vol. 5, No.2 |
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