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ABSTRACT
Title |
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Assay of Memantine Hydrochloride by UV Spectrophotometer |
Authors |
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Asra Ali Bahazeq, Wasfiya Noor Syeda, Nashra Fatima Isba, MD. Muzaffar-Ur-Rehman, Uzma Amatul Baqi |
Keywords |
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Memantine hydrochloride, Alzheimer’s disease, ICH guidelines, Validation, |
Issue Date |
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Jan 2019 |
Abstract |
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Memantine hydrochloride is a class of N-Methyl-D-Aspartase receptor antagonist used in the treatment of Alzheimer’s disease. The main aim of the present study was to develop a method to determine Memantine hydrochloride in tablet formulation which is simple, sensitive, precise and economical as per ICH guidelines. The method was validated at λ max of 254nm. Beer-Lambert’s was obeyed between the concentration ranges of 0.2-0.6µg/ml. A good linear relationship with correlation co-efficient of 0.998 was obtained and the LOD and LOQ values were 0.48µg/ml and 1.48µg/ml respectively. The method was also employed on the tablet formulation (Namenda) and the recovery was found to be 99.8%. |
Page(s) |
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27-30 |
ISSN |
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0975-9492 |
Source |
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Vol. 10, No.1 |
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