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ABSTRACT
| Title |
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Optimization of Solid state fermentation conditions for Biosynthesis of L-Asparaginase enzyme using WautersiaeutrophaNRRL B-2804 |
| Authors |
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YogitaLabrath, UjwalaGosavi, Vanita Nimje, Sadhana Sathaye |
| Keywords |
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Glycosylated hemoglobin, diabetes care, glycemic control, Jimma University Medical Center, Southwest Ethiopia |
| Issue Date |
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Oct 2018 |
| Abstract |
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Background: Long-term hyperglycemia promotes the development of complications and suboptimal well-being in patients with diabetes. A stringentglycemic control is a worldwide standard of diabetes care recommended in order to reduce such adverse health outcomes.The current study was aimed to undertake glycosylated hemoglobin (HbA1c) assay and assess the quality of glycemic control in Ethiopian diabetes care and identify simple patient related factors associated with poorcontrol. Methods: Hospital-based cross-sectional study with longitudinal components was conducted fromOctober 20to December15, 2015 among systematically selected adult ambulatory diabetic patientsat the outpatient clinic of Jimma University Medical Center, Southwest Ethiopia. At recruitment, blood samples for HbA1Cdetermination and sociodemographic characteristics were collected from each patient. In addition, patient charts were reviewed for recorded anthropometric data, diabetic duration and blood pressure. Based on their HbA1Ctest values, patients with HbA1C>8.0% were considered poor glycemic control. Binarylogistic regression was employed to identifyfactors associated with poorcontrol. A p-value <0.05 was considered statistically significant. Results: Among 162 diabetic patients included in this analysis, 84 (51.9%)subjects were male and/or Type 1diabetics;46 (30.5%) subjectswere below the age of 40 years; and every fourth subject was aged 60 years or older. Their diabetic duration ranged from 1 to 22 years with a mean ± SD of 5.4 ± 4.6 years. Sixty-seven (44.7%) subjects had diabetes for five years or longer. Mean ± SD of BMI and HbA1Cwas 24.3 ± 4.3kg/m2and 8.76 ± 2.6%, respectively. One-hundred and four (64.2%) patients had HbA1C values greater than 8.0%, indicating poor glycemic control. Poor glycemic control was associated with age (p= 0.001) in Type 1 diabetic patients. In Type 2 diabetics, prevalence of poor control was significantly higher among hypertensive (p= 0.029), female subjects (p=0.019) with longer duration of diabetes (p= 0.008). Conclusions:The overall state of glycemic control was unsatisfactory, and the condition was less favorable among hypertensive female subjects with advancing age and a longer history of diabetes. Overall diabetes treatment at the clinic needs to be improved with more intensive management alternatives to the vulnerable groups. |
| Page(s) |
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178-189 |
| ISSN |
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0975-9492 |
| Source |
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Vol. 9, No.10 |
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