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ABSTRACT
| Title |
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EVALUTION OF CARDIAC TONIC ACTIVITY OF METHANOLIC LEAF EXTRACT OF MORINGA OLEIFERA |
| Authors |
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B. Rajendar, K Bhavana, Ch Divya, M Swarna, K Anvesh |
| Keywords |
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Cardio tonic; Hypo dynamic heart; Positive inotropic effect; Moringa oleifera. Congestive heart failure |
| Issue Date |
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Jun 2017 |
| Abstract |
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The present study was undertaken to evaluate cardio tonic activity of methanolic leaf extract of Moringa oleifera. Different parts of the Moringa olifera species are used in India for a wide range of medicinal purposes. Cardio tonic effect of methanolic leaf extract of of Moringa oleifera was studied by using isolated frog heart perfusion technique (IFHP). Cardio tonic activity was studied on frog isolated heart .Methanolic leaf extract of Moringa oleifera as a test and digoxin is used as standard. Present study evaluated three parameters those are force of contraction, heart beats and cardiac output. A significant increased in height of force of contraction (positive inotropic effect) and decreased in heart rate (negative chronotrophic effect) and increased cardiac output was observed with the test extract. The present results indicated that a significant increase in height of force of contraction & decreasing heart rates was observed at the lower dose (1mg, 2mg & 4mg) of test extract. At the higher dose (8mg) decreasing contractions. Compared to digoxin, a drug with narrow therapeutic window, Moringa oleifera showed wide therapeutic window. |
| Page(s) |
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152-156 |
| ISSN |
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0975-9492 |
| Source |
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Vol. 8, No.06 |
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