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ABSTRACT
| Title |
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Evaluation of Safety of Tamra Bhasma through Sub acute (28 days) and Chronic toxicity (90 days) studies in Wistar rats |
| Authors |
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Sanjaya Kumar Y.R, Sudesh Gaidhani N, Thamizh Selvam. N, Acharya. M .V |
| Keywords |
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Tamra Bhasma; rats: Sub acute and chronic toxicity |
| Issue Date |
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Nov 2016 |
| Abstract |
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Tamra bhasma, an Ayurvedic metallic preparation evaluated for safety in Wistar rats by sub acute (28 days) and chronic toxicity (90 days) studies. The test drug was administered to three groups of rats at therapeutic dose, 5 times of therapeutic dose and 10 times of therapeutic dose levels. No mortality or signs of toxicity was observed in Wistar rats during both the studies. Hematology and biochemical values did not alter significantly between test and control group. Internal organs did not reveal structural changes suggestive of toxicity upon gross examination and histopathology investigation.Tamra bhasma was found to be safe up to 13.5 mg/kg body weight in Wistar rats. |
| Page(s) |
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431-439 |
| ISSN |
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0975-9492 |
| Source |
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Vol. 7, No.11 |
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