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ABSTRACT
Title |
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FORMULATION AND EVALUATION OF ORAL HERBAL GRANULES FOR ASTHMA |
Authors |
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AmrutaAvalaskar, PawanKudale, Pratik Khandelwal, SaieswariNatesan, Pooja Shah, RashmiJadhav |
Keywords |
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Justicia adhatoda. granules, Vasaka granules, asthma. |
Issue Date |
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October 2016 |
Abstract |
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Purpose: Asthma is a chronic disease of the bronchiwhich usually requires continuous medical care. According to WHO, about 235 million people currently suffer from asthma. It is the most common chronic disease prevalent among children. Approaches in formulating novel herbal drug formulations that are easy to administer especially for chronic diseases can form a valuable therapy in addition to overcoming the side effects and disadvantages of synthetic drugs. Method: Vasaka is easily available and largely used herb for asthma. Oral granules of dried aqueous extract of Justicia adhatoda (Vasaka)(125mg per dose i.e. per gram) were formulated especially for paediatric patients using wet granulation technique, as they show noncompliance towards solid preparations such as tablets and capsules due to fear of chocking and syrups on account of their bitter taste. The bitter taste of Vasaka extract was masked with sucralose, flavouring agents and citric acid. Results and conclusions: The formulation was prepared with excipients and flavouring gents to improve patient compliance. Citric acid which also acts as sialagogue was used, thereby obviating the need of consuming water while administering the formulation.The granules apart from showing excellent flow propertiesdisintegrate within 20 seconds in oral cavity. As wet granulation technique is used, the process is cheaper and less time consuming as compared to production of tablets, capsules and syrups. Hence, this formulation can serve as an ideal candidate for commercialization on large scale and an inexpensive therapy as compared to currently available formulations in the market. |
Page(s) |
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382-389 |
ISSN |
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0975-9492 |
Source |
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Vol. 7, No.10 |
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