ISSN : 0975-9492
CODEN : IJPSQQ





INTERNATIONAL JOURNAL OF PHARMA SCIENCES AND RESEARCH


Open Access

This website is certified by Health On the Net Foundation. Click to verify.

This site complies with the HONcode standard for trustworthy health information:
verify here.

ABSTRACT

Title : FORMULATION AND IN-VITRO EVALUATION OF GASTRORETENTIVE DRUG DELIVERY SYSTEM FOR NEVIRAPINE
Authors : Mahajan Ashwini, Dr. Sarode S. M., Prof. Sathe B.S., Dr. Vadnere G.P.
Keywords : Floating matrix, nevirapine, potent antiviral, direct compression, floating lag time.
Issue Date : May 2015
Abstract :
Floating matrix tablets of nvirapine were developed to prolong gastric residence time and increase its bioavailability. In the present investigation it was thought worthwhile to develop a gastric floating drug delivery system of nevirapine to improve the efficacy of dosage form. Inevirapine a potent antiviral drug with low toxicity used in treatment of HIV. It has maximum absorption in stomach and upper part of small intestine. Due to low gastric retention time, the bioavailability of drug is low as large portion of drug misses the absorption window. The tablets were prepared by direct compression technique, using polymers such as Hydroxy propyl methylcellulose(HPMC, Methocel K100M), Carbopol and Sodium alginate alone or in combination. Sodium bicarbonate and Citric acid was incorporated as a gas-generating agent. The effects of sodium bicarbonate and citric acid on drug release profile and floating properties were investigated. All the tablets passed the compendial tests and other tests like weight variation, drug content, hardness, friability. The floating time was found to be more than 12 hrs. All the tablets showed the floating lag time of less than 10minute. The dissolution study was carried out in 0.1 N HCL using USP type II apparatus.
Page(s) : 823-829
ISSN : 0975-9492
Source : Vol. 6, No.5