ISSN : 0975-9492
CODEN : IJPSQQ





INTERNATIONAL JOURNAL OF PHARMA SCIENCES AND RESEARCH


Open Access

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ABSTRACT

Title : IN SITU GELS- A NEW TRENDS IN OPHTHALMIC DRUG DELIVERY SYSTEMS
Authors : Ramanjit Saini, Seema Saini, Gurpreet Singh, Dr. Angshu Banerjee
Keywords : In situ gel, pH triggered in situ gelation, Temperature dependent in situ gelation, Ion activated in situ gelation.
Issue Date : May 2015
Abstract :
Ophthalmic drug delivery is one of the most interesting and challenging endeavor facing the pharmaceutical scientist. The conventional ocular drug delivery systems like solutions, suspensions, and ointments show drawbacks such as increased precorneal elimination, high variability in efficiency, and blurred vision respectively so there was a need for developing advanced drug delivery system. In situ forming polymeric formulations were developed to overcome the conventional drug therapy drawbacks these systems are in solution form before administering in the body, but once administered these systems undergo gelation. The formation of gels depends on factors like change in a specific physico-chemical parameter (pH, temperature, ion-sensitive) by which the drug gets released in a sustained and controlled manner. These systems were evaluated for drug content, clarity, pH, gelling capacity, viscosity, in vitro drug release studies, texture analysis, sterility testing , isotonicity evaluation, accelerated studies and irritancy test. FT-IR spectroscopy was used to know drug and polymer incompatibilities.
Page(s) : 886-890
ISSN : 0975-9492
Source : Vol. 6, No.5