ISSN : 0975-9492
CODEN : IJPSQQ





INTERNATIONAL JOURNAL OF PHARMA SCIENCES AND RESEARCH


Open Access

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ABSTRACT

Title : HEPATO-PROTECTIVE EFFECT OF ARTESUNATE ON CARBON TETRACHLORIDE-INDUCED TOXICITY IN RATS
Authors : Akinola Franklin Folasele, Ukpanukpong, Richard Undigweundeye
Keywords : Artesunate, Carbon Tetrachloride, Plasma Transaminases, Albumin
Issue Date : May 2015
Abstract :
Purpose: In the present study, the investigation of the protective effect of Artesunate in experimental acute liver damage induced by CCl4 was carried out. Methodology: Forty wistar rats were equally allocated to four study groups. The first group was designated as the distilled water control group (group 1). The second group was given oral CCl4 (0.75ml/kg body weight diluted 1:1 in between 80) for 3 days (group 2). The third group (group 3) was given oral Artesunate (50mg/kg body weight) for 3 days followed by CCl4 oral administration with the same dose given to group 2 and the fourth group (group 4) was given oral artesunate (50mg/kg body weight) for 3 days. Body weight before and after the experiment was noted and plasma AST, ALT, ALP and ALB levels were studied as markers of hepatotoxicity. Results: Plasma AST level was significantly higher in group 2, in comparison to group 1 (P < .05). Also increase in levels of ALT and ALP was noted in group 2 as compared to group 1. ALT, AST and ALP were increased in group 4. Conclusion: Observed improvement in plasma AST, ALT and ALP was recorded in group 3 and all these suggested that Artesunate has possible hepatoprotective effect on hepatocellular damage due to toxicity and it could also have hepatotoxic effect when administered in high dose in experimental animals.
Page(s) : 869-873
ISSN : 0975-9492
Source : Vol. 6, No.5