Abstract of INTERNATIONAL JOURNAL OF PHARMA SCIENCES AND RESEARCH (IJPSR)

ABSTRACT

Title

EFFECT OF AQUEOUS LEAF EXTRACT OF Moringa oleifera ON SOME RENAL FUNCTION INDICES OF RATS

Authors

Okwari O. O, Alagwu.E.A, Dasofunjo K, Okwari .K .O, Obi L

Keywords

Bile, Uric acid Moringa oleifera, Serum Creatinine, Serum Electrolytes.

Issue Date

April 2015

Abstract

Purpose:The study was designed to investigate the effect of aqueous leaf extract of M.oleifera on bile secretion and serum electrolytes in rats. Methodology: Eighteen (18) Albino Wistar rats weighing between 180-220g body weights were assigned into three groups (i, ii and iii) of six rats each after acclimatization for seven (7) days. Group 1 (control) received standard feed and water while Groups 11 and 111 (low and high dose groups respectively) received 300mg/kg body weight and 600mg/kg body respectively in addition to food and water daily for 28days.The rats were sacrificed 24hours after an overnight fast using chloroform-ether anesthesia in ratio 1;1. The blood as well as biliary samples was collected for determination of electrolytes. Result: The result showed that bile secretion was significantly (P<0.001) increased in the high dose group but was significantly (P<0.001) decreased in the low dose group when compared with the control. The biliary bicarbonate level were significantly (P<0.001) decreased in test groups while there was significant (P<0.001) increased in serum bicarbonate levels compared with control. Serum and biliary phosphate levels were significantly (P<0.001) decreased in test groups compared with control. Sodium levels in serum and bile were significantly (P<0.001) decreased, while serum potassium levels were significantly (P<0.001) decreased in test groups but were significantly (P<0.001) increased test group compared with control. Serum bilirubin levels were significantly lowered in low dose but increased in high dose group compared with control. Uric acid levels in bile and serum were significantly (P<0.001) decreased in test groups. Creatinine was significantly reduced in low dose compared with control following the administration of the extract. Urea and T. cholesterol were significantly (P<0.001) reduced in serum but significantly increased in bile respectively.Conclusion: It appears that M.oleifera may reduce blood pressure following its marked effect on sodium levels

Page(s)

777-782

ISSN

0975-9492

Source

Vol. 6, No.4