ISSN : 0975-9492
CODEN : IJPSQQ





INTERNATIONAL JOURNAL OF PHARMA SCIENCES AND RESEARCH


Open Access

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ABSTRACT

Title : ANTI-STRESS ACTIVITY OF EUPHORBIA THYMIFOLIA L. AQUEOUS ROOT EXTRACT IN FEMALE RATS
Authors : SIVAPRASAD GUDIPUDI, DAYANAND SUBRAO PURANIK, RAMOJI ALLA, UPENDRANADH AJJARAPU, THIRUPATHI REDDY KISTAMMAGARI
Keywords : Euphorbia thymifolia L. root, Forced swimming stress, Restraint stress, Estrous cycle, Organ weight.
Issue Date : April 2015
Abstract :
Euphorbia thymifolia root is having the protective effect against female reproductive dysfunctions. This study is to evaluate the anti-stress activity of aqueous extract of Euphorbia thymifolia root in treating female reproductive dysfunction induced by stress. Forced swimming stress (15min/day for 28 days) and restraint stress (3h/day for 28 days) were the methods employed to induce female reproductive dysfunction in rats. Aqueous extract of Euphorbia thymifolia root was given to rats in two doses, 100 mg/kg and 200 mg/kg for 28 days along with induction of stress and its effectiveness was assessed by observing changes in estrous cycle and organs weight. The results were analyzed by using one-way ANOVA followed by Dunnett’s test. Euphorbia thymifolia root extract showed a significant protective effect which is evident by decrease in the duration of proestrous and increase in duration of estrous, metestrous, and diestrous phases. Whereas the weight of adrenal glands noticeably decreased in aqueous extract treated group confirming the anti-stress activity which was found to be dose dependent. The anti-stress activity may be due to the presence of various phytochemical constituents like alkaloids, flavonoids and other constituents present in the Euphorbia thymifolia root.
Page(s) : 640-644
ISSN : 0975-9492
Source : Vol. 6, No.4