|
|
ABSTRACT
| Title |
: |
MOUTH DISSOLVING FILM: A NOVEL APPROACH TO DELIVERY OF LISINOPRIL |
| Authors |
: |
POONAM PHASATE, VIJAYALAXMI CHAVAN, NITIN TRIBHUVAN, POONAM PADAMWAR |
| Keywords |
: |
Mouth dissolving film, HPMC, PVA, Lisinopril, Solvent casting method. |
| Issue Date |
: |
February 2015 |
| Abstract |
: |
Purpose: Orodispersible dosage forms are promising new approaches for drug delivery for patients. They are easy for application, no need to drink high amounts of water or swallow large solid dosage forms. The aim of this study is to formulate and evaluate the mouth dissolving film of Lisinopril as an ACE inhibitor used to treat high blood pressure (hypertension), congestive heart failure and improved bioavailability of drugs as compared to conventional solid oral dosage forms. Method: The films were prepared using combination of Hydroxy propylmethyl cellulose E15 and PVA (polyvinylalcohol) polymers by solvent casting method. Glycerine as plasticizer, aspartame as sweetener. Result: The IR spectral studies showed no interaction between drug and the polymers. Satisfactory results obtained when subjected to physico-chemical tests such as weight uniformity, thickness, folding endurance, drug content and disintegration time. Films in vitro drug release studies also done by using USP dissolution apparatus. In case of F4 and F5 formulations about 99.529% and 95.29% of drug was released at 2min. Conclusion: The Lisinopril mouth dissolving film was formulated. The given film disintegrates within eleven second which release drug rapidly and gives action. |
| Page(s) |
: |
398-405 |
| ISSN |
: |
0975-9492 |
| Source |
: |
Vol. 6, No.2 |
|
Copyright to ENGG Journals Publications
